FLUPHENAZINE DECANOATE PACKAGE INSERT PDF

Rotate the site of injection to avoid irritation or sterile abscess formation with repeat administration. Intramuscular Depot injection (fluphenazine decanoate or . PACKAGE LEAFLET: INFORMATION FOR THE USER. Modecate® 25mg/ml Injection fluphenazine decanoate. Is this leaflet hard to see or read? Phone . ADMINISTRATION). Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients or psychoneurotic.

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Major Patients should generally be counseled to avoid alcohol use during phenothiazine therapy, due to additive central nervous system CNS depression and the potential to increase psychomotor impairment. Phenothiazine antiemetics are also central dopamine antagonists and have been associated with extrapyramidal symptoms and rarely, neuroleptic malignant syndrome.

If concomitant use is necessary, monitor ECGs for QTc prolongation and monitor electrolytes; correct any electrolyte abnormalities as clinically appropriate. Monitor for sedation and respiratory depression. Concurrent use of thiazide diuretics may cause hypotension. The syndrome is characterised by hyperthermia, together fluphenazinw some or all of the following: Minor Coadministration of gemtuzumab ozogamicin with fluphenazine may increase the potential for additive QT prolongation fluphenazone risk of torsade de pointes TdP.

Clinicians should note that antimuscarinic effects may be seen not only on GI smooth muscle, but also on bladder function, the eye, and temperature regulation. Minor Halogenated anesthetics should be used decznoate and with close monitoring with fluphenazine.

Cases of venous thromboembolism VTE have been reported with antipsychotic drugs. Ethanol ingestion may further impair cognitive and motor skills and patients should be advised to avoid use of alcoholic beverages. Use fluphenazine with caution in patients with cardiac disease or other conditions decanoatte may increase the risk of Inesrt prolongation including cardiac arrhythmias, congenital long QT syndrome, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances.

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Piperazine phenothiazine antipsychotic; 2 mg orally equivalent to mg of oral chlorpromazine, the prototype antipsychotic; depot IM injections i. Fluphenazine is contraindicated for use in patients in comatose states i.

Initially, 1 to 2. Because antipsychotics can cause or exacerbate hyponatremia and SIADH and the elderly are at increased risk of developing these conditions, sodium levels should be closely monitored when starting or changing dosages of antipsychotics in older adults.

Modecate Injection 25mg/ml – Summary of Product Characteristics (SmPC) – (eMC)

Moderate Phenothiazines can potentiate the CNS-depressant action of other drugs such as skeletal muscle relaxants. Chlorpromazine may interfere with the metabolism of phenytoin and thus precipitate fluphenzaine toxicity. Initially, 1 mg to 2. Phenothiazines may potentiate hypotension caused by hypovolemia, the presence of antihypertensive drugs, or a dehydrated state.

The impact of in utero exposure to antidepressants or antipsychotics compared to no psychotropic exposure was assessed in infants 6 months of age using the Infant Neurological International Battery INFANIBa neuromotor exam that tests posture, tone, reflexes, and motor skills, and using a visual habituation paradigm of a neutral female face. The concomitant administration of phenothiazines may produce additive effects. Prior to the third dose, determine if the patient may be able to have the dose flphenazine, to compensate for accumulation toward steady state.

Theoretically, these phenothiazines may increase the risk insdrt QT prolongation if coadministered with drugs with a risk of QT prolongation.

Modecate Injection 25mg/ml

Although the full pharmacologic impact of increased tramadol exposure is unknown, close monitoring for serious adverse effects, such as seizures, is advisable. Phenothiazines may also induce hyperprolactinemia and galactorrhea, and thus may interfere with proper lactation. These effects have varied in severity ranging from self-limited to requiring intensive care unit stays and prolonged hospitalization.

The likelihood of pharmacodynamic interactions varies based upon the individual properties of the co-administered antipsychotic agent. Antipsychotics have been reported to disrupt the body’s ability to reduce core body temperature presumably through effects in the hypothalamus, and they predispose patients to hyperthermia.

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Lower doses than usually prescribed for either the phenothiazine or the TCA may be required. Show table of contents Hide table of contents 1.

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The physiology of the infant should be considered when evaluating the risk of exposure to phenothiazines. Pharmaceutical form Solution for Injection Pale yellow clear, oily liquid. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes Padkage. Tardive dyskinesia is a syndrome of potentially irreversible, involuntary, dyskinetic movements that may develop in patients treated with antipsychotics. Additive extrapyramidal effects have also been noted.

Oedema has been reported with phenothiazine medication. Treatment is symptomatic and supportive, including maintaining vital signs, airway, stable body temperature, and fluid and electrolyte balance. In addition, serotonin syndrome may occur during use of tramadol with medications that impair its metabolism. A fall risk assessment should be completed when initiating an antipsychotic in patients with conditions, diseases, or concurrent medication use that could exacerbate orthostasis.

Keep the ampoules in the outer carton in order to protect from light. Moderate Additive effects may be seen when phenothiazines are used concomitantly with other drugs with antimuscarinic activity, such as clemastine, a sedating H1-blocker. Major Avoid concurrent use of phenothiazines and bromocriptine when possible. ALERT Watch for evidence of neuroleptic malignant syndrome extrapyramidal effects, hyperthermia, autonomic disturbancewhich is rare but commonly fatal.

Droperidol administration is associated with an established risk for QT prolongation and torsades de pointes TdP.

Monitor patients for sedation or respiratory depression.